Biophysical properties of mitochondrial calcium uniporter in metabolic syndrom
نویسندگان
چکیده
منابع مشابه
Mitochondrial calcium uniporter, MiRNA and cancer
Mitochondria receive calcium (Ca(2+)) signals from endoplasmic reticulum (ER) and decode them into pro-apoptotic inputs, which lead to cell death. Therefore, mitochondrial Ca(2+) overload is considered a fundamental trigger of the apoptotic process, and several oncogenes and tumor suppressors modify the activity of protein involved in Ca(2+) homeostasis to control apoptosis. The identification ...
متن کاملCalcium Signaling: Double Duty for Calcium at the Mitochondrial Uniporter
Uptake of Ca(2+) by mitochondria serves as a regulator of a number of important cellular functions, including energy metabolism, cytoplasmic Ca(2+) signals, and apoptosis. Recent findings reveal that the process of Ca(2+) uptake by the mitochondrial uniporter is itself regulated by Ca(2+) in a temporally complex manner.
متن کاملThe Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.
In the heart, augmented Ca(2+) fluxing drives contractility and ATP generation through mitochondrial Ca(2+) loading. Pathologic mitochondrial Ca(2+) overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardiomyocyte death. Mitochondrial Ca(2+) uptake is primarily mediated by the mitochondrial Ca(2+) uniporter (MCU). Here, we generated mice with ad...
متن کاملThe Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders
The mitochondrial calcium uniporter (MCU)-a calcium uniporter on the inner membrane of mitochondria-controls the mitochondrial calcium uptake in normal and abnormal situations. Mitochondrial calcium is essential for the production of adenosine triphosphate (ATP); however, excessive calcium will induce mitochondrial dysfunction. Calcium homeostasis disruption and mitochondrial dysfunction is obs...
متن کاملReconstitution of the mitochondrial calcium uniporter in yeast.
The mitochondrial calcium uniporter is a highly selective calcium channel distributed broadly across eukaryotes but absent in the yeast Saccharomyces cerevisiae. The molecular components of the human uniporter holocomplex (uniplex) have been identified recently. The uniplex consists of three membrane-spanning subunits--mitochondrial calcium uniporter (MCU), its paralog MCUb, and essential MCU r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2020
ISSN: 1878-6480
DOI: 10.1016/j.acvdsp.2020.03.158